Twórca instytucjonalny:

Department of Experimental and Clinical Neuropathology MMRI

Współtwórca:

M.Dąmbska, dr hab.

Opis:

Clinical, anatomical and histological diagnosis

Abstrakt:

Histological diagnosis: Maple Syrup Urine Disease (MSUD). Autopsy examination of 3-month-old baby was performed. Neuropathological evaluation in light microscopy was based on brain paraffin sections stained by Hematoxylin-eosin and Cresyl violet stain as well as Kluver-Barrera and Kanzler-Arendt methods. Additionally, frozen section was stained by Sudan III.Very weak coloring in staining for myelin was noticed in all sections of the white matter. Partial myelination was seen in the short tracts of the basal ganglia, in the axis of some convolutions of the cerebral hemispheres and in the cerebellar hemispheres. In poorly myelinated areas a tissue spongiosis was observed. Impaired myelination was accompanied by fibrous gliosis, more pronounced in structures with severe spongiosis and in their close vicinity. In Sudan III staining, small fat droplets around glial nuclei were seen in some areas, e.g. in the optic tract and partially in the cerebellar pathways, with a surprisingly small number of fat droplets around the vessels. In other non-myelinated areas Sudan III staining was negative

Format:

pdf

Identyfikator zasobu:

oai:rcin.org.pl:193504

Język:

pol

Język streszczenia:

eng

Prawa:

Creative Commons Attribution BY 4.0 license

Zasady wykorzystania:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitalizacja:

Mossakowski Medical Research Institute PAS

Lokalizacja oryginału:

Library of the Mossakowski Medical Research Institute PAS

Dofinansowane ze środków:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Dostęp:

Open