Subtitle:

Proc of the 11nd International Symposium on Nucleic Medicine, Carlsbad, 1978

Description:

s.209-214

Type of object:

Książka/Rozdział

Abstract:

Adult Albino rats (290) were investigated under aether anaesthesia in the following groups: 1. control 2. unilateral ligation of the common carotid artery 3. bilateral ligation of these arteries 4. unilateral ligation of the c. c. artery and exposure to anoxia or hypoxia (4 % 02). I—HSA, vTc04, Na I, Na Br, I—4—I—antipyrine and Se — selenomethionine were injeoted i. v. in all of these groups. Parallel optic microscopic and histochemical (glycogen) studies vere performed. The activity of each hemisphere and of a blood sample were measured in a well — type scintillation oounter mainly between 10 min and 5 h and in some eases up to 96 h after induotion of patho-logy. The results were expressed for each hemisphere as: ifD/g corrected for body weight, ratio of brain/blood specific activities and M D in whole blood. In one group of animals, whole blood volume and the brain blood volume were determined. Compara-tive transport into normal cerebral tissue was as foliows: |131I—4—I—antipyrina 75Se—selenomethionine Na82Br Na131J 9SmTcO ,13,J —HSA. There were no statistical differences as compared with the control group in the transport of these compounds into brain tissue after unilateral and bilateral ligation of the c. c. artery. Anoxia (5 min) and hypoxia up to 3 h eaused no changes in transport of these compounds. In the ischaemic—hypoxic group penetration of these compounds into the damaged hemisphere was much higher in the majority of cases. The authors suggest that the ischaemic factor in this model is mainly responsible for the development of oedema with progressive damage of brain

Detailed Resource Type:

Artykuł

Format:

application/pdf

Resource Identifier:

oai:rcin.org.pl:69670

Language:

eng

Rights:

Licencja Creative Commons Uznanie autorstwa 4.0

Terms of use:

Zasób chroniony prawem autorskim. [CC BY 4.0 Międzynarodowe] Korzystanie dozwolone zgodnie z licencją Creative Commons Uznanie autorstwa 4.0, której pełne postanowienia dostępne są pod adresem: ; -

Digitizing institution:

Instytut Medycyny Doświadczalnej i Klinicznej im. M. Mossakowskiego Polskiej Akademii Nauk

Original in:

Biblioteka Instytutu Medycyny Doświadczalnej i Klinicznej im. M. Mossakowskiego PAN

Projects co-financed by:

Program Operacyjny Polska Cyfrowa, lata 2014-2020, Działanie 2.3 : Cyfrowa dostępność i użyteczność sektora publicznego; środki z Europejskiego Funduszu Rozwoju Regionalnego oraz współfinansowania krajowego z budżetu państwa

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