Subtitle:

L-lysine biosynthesis

Publisher:

Komitet Biotechnologii PAN ; Instytut Chemii Bioorganicznej PAN

Abstract:

Amino acid fermentation has grown into a global industry. Market development has been particularly dynamic for the flavor-enhancer glutamate and animal feed amino acids: L-lysine, DL-methionine, L-threonine, and L-tryptophan. These amino acids are manufactured using high performance Corynebacterium glutamicum. Production strains have been traditionally constructed by repeating random mutation and selection. This classical method has generated a variety of mutation, such as auxotrophs, analog-resistant mutants and transport mutants. The complete genome sequence of the wild-type strain of C. glutamicum has been established and analysed to improve the understending of the molecular biology and physiology of this organism. A novel methodology that merges genomics with classical strains improvement has been developed and applied for the reconstruction of classicaly derived production strains. In addition, modern technologies such as metabolic flux analysis and metabolic control analysis have enabled quantification of carbon fluxes. The fundamental information obtained has been the basis for further strain improvement.

Relation:

Biotechnologia, vol.80, 1 (2008)-.

Volume:

80

Issue:

1

Start page:

53

End page:

70

Detailed Resource Type:

Artykuł

Format:

application/pdf

Resource Identifier:

0860-7796 ; oai:rcin.org.pl:74059

Source:

Biblioteka Instytutu Chemii Bioorganicznej PAN

Language:

pol

Language of abstract:

eng

Temporal coverage:

2008

Rights:

Licencja Creative Commons Uznanie autorstwa-Na tych samych warunkach 4.0

Terms of use:

-

Digitizing institution:

Instytut Chemii Bioorganiczneji Polskiej Akademii Nauk

Original in:

Instytut Chemii Bioorganiczneji Polskiej Akademii Nauk

Projects co-financed by:

Program Operacyjny Polska Cyfrowa, lata 2014-2020, Działanie 2.3 : Cyfrowa dostępność i użyteczność sektora publicznego; środki z Europejskiego Funduszu Rozwoju Regionalnego oraz współfinansowania krajowego z budżetu państwa

Access:

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