Wydawca:

Zakład im. Ossolińskich - Wydawnictwo Polskiej Akademii Nauk

Miejsce wydania:

Wrocław ; Warszawa ; Kraków

Typ obiektu:

Journal/Article

Abstrakt:

Studies on the influence of sera from patients with Wilson’s disease treated with d-penicilamine upon morphology and immunomorphology of astrocytes in organotypic cultures of newborn rat cerebella were performed. The pathological sera applied were characterized by significant reduction of both copper level and céruloplasmine activity. Remarkable differences were found as compared with the influence of sera from untreated patients. They consisted in greater cellula-rity of cultures and predominance of astrocytic hypertrophy over nonspecific cel¬lular degeneration. However, astrocytic abnormalities, typical for Wilsonian gliopathy such as Alzheimer cells, type II and Opalski cells were also present. Intensity of degenerative changes of astrocytes and frequency of Alzheimer cells type II and Opalski cells appearance were correlated with the advancement of the disease process and degree of céruloplasmine activity reduction. All ab¬normal astrocytes both showing features of hypertrophy and degeneration gave positive immunofluorescent reaction with anti-GFAP serum. So did Alzheimer cells, type II and Opalski cells. The authors supposed that less severe astrocytic abnormalities as compared with those obtained with sera from untreated patients were due to lowered copper content in sera used in present experiments. However,disturbed pro¬portion between bound and free copper in sera resulting from reduction of céru¬loplasmine activity could be responsible for the appearance of Wilsonian gliopathy features, even unde rconditions of lowered general content of copper.

Czasopismo/Seria/cykl:

Neuropatologia Polska

Tom:

24

Zeszyt:

2

Strona pocz.:

169

Strona końc.:

181

Szczegółowy typ zasobu:

Article

Format:

pdf

Identyfikator zasobu:

oai:rcin.org.pl:68755

Język:

pol

Język streszczenia:

eng ; rus

Prawa:

Creative Commons Attribution BY 4.0 license

Zasady wykorzystania:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitalizacja:

Mossakowski Medical Research Institute PAS

Lokalizacja oryginału:

Library of the Mossakowski Medical Research Institute PAS

Dofinansowane ze środków:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Dostęp:

Open