Tytuł:

miR-122 silencing a novel therapy for HCV infections?

Inny tytuł:

miR-122 silencing a novel therapy for HCV infections?

Twórca:

Tyczewska, Agata ; Bąkowska- Żywicka, Kamila

Wydawca:

Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS

Data wydania/powstania:

2010

Opis:

prace przeglądowe

Temat i słowa kluczowe:

biotechnologia

Abstrakt:

Hepatitis C (HCV) infection is one of major epidemiological, medical and social concerns in the modern world. In Poland, around 700 000 people have HCV, worldwide the number is as high as 170-180 million. Current treatment consists of pegylated interferon-alpha and ribavirin, but is limited by the resistance of the viral strains, adverse effects, and high costs. Since HCV infection is a major cause of liver cirrhosis and hepatocellular carcinoma, it is necessary to develop novel antiviral compounds with improved virological response and reduced toxicity. In this article, we describe the results of recent trials to fight the HCV infection using an antagonising miR-122 oligo-LNA probe in primates.

Czasopismo/Seria/cykl:

Biotechnologia, vol.90, 3 (2010)-.

Tom:

90

Zeszyt:

3

Strona pocz.:

29

Strona końc.:

35

Typ zasobu:

Text

Szczegółowy typ zasobu:

Article

Format:

application/pdf

Identyfikator zasobu:

IChB B-85

Źródło:

Biblioteka Instytutu Chemii Bioorganicznej PAN

Język:

pol

Język streszczenia:

eng

Zakres czasowy:

2010

Prawa:

Creative Commons Attribution BY-SA 4.0 license

Zasady wykorzystania:

Copyright-protected material. [CC BY-SA 4.0] May be used within the scope specified in Creative Commons Attribution BY-SA 4.0 license, full text available at:

Digitalizacja:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Lokalizacja oryginału:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Dofinansowane ze środków:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Dostęp:

Open