Title:

Aktywność ludzkiej rybonukleazy Dicer wspierająca parowanie cząsteczek kwasów nukleinowych: odkrycie, charakterystyka biochemiczna i potencjalne znaczenie biologiczne

Creator:

Pokornowska, Maria

Date issued/created:

2020

Location:

Poznań

Subject and Keywords:

nauki chemiczne

Abstract:

Dicer ribonucleases play an important role in the biogenesis of small regulatory RNAs by cleaving singlestranded precursors adopting stem-loop structures (pre-miRNAs) as well as double-stranded RNAs (dsRNAs)into short RNA duplexes containing functional microRNAs (miRNAs) or small interfering RNAs (siRNAs),respectively. miRNA or siRNA together with Argonaute (Ago) proteins form RNA-induced silencing complexwhich mediates post-transcriptional gene silencing. However, there is a growing number of reports describingDicer’s functions that are not related to its ribonuclease activity, and the biogenesis of small regulatory RNAs.

Start page:

1

End page:

162

Resource type:

Text

Detailed Resource Type:

PhD Dissertations

Format:

application/pdf

Language:

pol

Language of abstract:

eng

Rights:

Creative Commons Attribution BY-SA 4.0 license

Terms of use:

-

Digitizing institution:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Original in:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open