Title:

Exploring Nucleoside Boranephosphonate Chemistry – Mechanistic and Synthetic Studies

Creator:

Gołębiewska, Justyna

Date issued/created:

2020

Description:

Promotor: Prof. dr hab. Jacek Stawiński; Promotor pomocniczy: Dr Joanna Romanowska

Location:

Poznań

Abstract:

Nucleoside boranephosphonates are an important class of nucleotide analoguesin which one of the non-bridging oxygen atom has been replaced by a borane moiety (-BH3).The significant structural similarity to natural nucleotides and their higher stability in the cellmedium make these analogues extremely useful in biological research. In contrast to theirchemical and biological properties, reactivity of the borane group itself in these compoundshas been poorly explored so far. From the chemistry point of view, modifying and carryingout transformations within this group opens new possibilities for application ofboranephosphonate derivatives, e.g., as masking groups, chemical markers in post-syntheticmodifications of oligonucleotides, or a new type of pharmacophores. These stimulated myinterest in this class of compounds and ultimately, the reactivity of the borane group ofnucleoside boranephosphonate under oxidative conditions with diverse N-nucleophilesbecame subject of my PhD thesis.

Start page:

1

End page:

154

Resource type:

Text

Detailed Resource Type:

PhD Dissertations

Language:

pol

Language of abstract:

pol ; eng

Rights:

Creative Commons Attribution BY-SA 4.0 license

Terms of use:

-

Digitizing institution:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Original in:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open