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File of histopathological evaluation of nervous system diseases (1965)- nr 124/65
Institutional creator:Department of Experimental and Clinical Neuropathology MMRI
Contributor: Place of publishing: Date issued/created: Description:Clinical, anatomical and histological diagnosis
Subject and Keywords:Vascular disease- encephalomacia
Abstract:Histological diagnosis: Ischemia diffusa cerebri Status lacunaris. Focus encephalomalacias inveterates bulbi. Arteric et arteriolsclerosis gradu mediocri. Putrefactio. Autopsy examination of 72-year-old patient was performed. Neuropathological evaluation in light microscopy was based on brain paraffin sections stained with Hematoxylin-eosin, Heidenhain and Van Gieson's method.On the specimens taken from the medulla, a focus of malacia filled with macrophages with a gemistocytic reaction in the surrounding tissue was observed. On the uppermost section (borderline of the pons) no macrophages were found, only numerous vessels of various diameters were visible in the large post-malacia cavity. Numerous small thinning of the tissue were present throughout the left half of the medulla and in the midline of the grisenum portis and left midbrain. Within the cerebellum, diffuse gliosis and thinning of the white matter and Bergman glium were evident. In the brain, extensive generalized ischemic lesions of the cortex and white matter, both almost without glial reaction and without macrophages, were notable. There was no apparent difference in tissue density in samples from the right (spared) and left (softened) hemispheres. Besides, the basal nuclei showed status lacunaris with moderate glial reaction. Extravasated blood cells were seen in the subarachnoid space. Cellular reaction was evident in the thickened soft meninges. The arteries of the cerebral hemispheres had thick muscle layer, small ones showed fibrous changes. Vitreous changes of the vessel walls were seen only within the brain stem. Accurate assessment of cellular changes and edema was impossible due to the long postmortem period /72 hours/.
Resource type: Format: Language: Language of abstract: Rights:Creative Commons Attribution BY 4.0 license
Terms of use:Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -
Digitizing institution:Mossakowski Medical Research Institute PAS
Original in:Library of the Mossakowski Medical Research Institute PAS
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