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Acyclic oligonucleotides analogues obtained via Click Chemistry
Creator: Date issued/created: Description:Promotor:Prof. UAM dr hab. Jan Milecki ; Praca przedstawiona Radzie Naukowej Wydziału Chemii Uniwersytetu im. A. Mickiewiczacelem uzyskania stopnia naukowego doktora nauk chemicznych
Subject and Keywords: Abstract:Copper(I) Catalyzed Alkyne-Azide Cycloaddition strongly influenced onDNA-based synthesis of novel oligonucleotides derivatives. Possibility of creating new kindof chain linkage, 1,4-disubstituted 1,2,3-triazole replacement of native phosphodiester, devoidof negative charge and nuclease resistant, appears to be extremely interesting. This allows todesign new class of nucleic acid analogues, similar in its DNA-mimicking properties toPNA’s
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Terms of use: Digitizing institution:Institute of Bioorganic Chemistry of the Polish Academy of Science
Original in:Institute of Bioorganic Chemistry of the Polish Academy of Science
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