Title:

Zastosowanie AAV jako wektorów w terapii genowej

Subtitle:

Adeno-associated virus vectors in gene therapy

Creator:

Kamieniarz, Kinga ; Goździcka-Józefiak, Anna

Publisher:

Komitet Biotechnologii PAN ; Instytut Chemii Bioorganicznej PAN

Date issued/created:

2005

Subject and Keywords:

biotechnologia

Abstract:

The development of targeted vectors, capable of tissue-specific transduction, remains one of the most important aims of vector modification for gene therapy applications. The gaining popularity of recombinant vectors based on adeno-associated viruses (rAAV) in gene therapy can be attributed to their lack of pathogenicity, added safety due to their replication defectiveness, relatively low immunogenicity and their ability to mediate long-term expression in a variety of tissues. The major shortcoming of these vectors is their small packaging capacity. AAV vectors have already broad utility in the therapy of many diseases, including neurological disorders and various types of cancer. Moreover, they can also serve as transfer vehicles for DNA vaccines.

Relation:

Biotechnologia, vol.68, 1 (2005)-.

Volume:

68

Issue:

1

Start page:

79

End page:

94

Resource type:

Tekst

Detailed Resource Type:

Artykuł

Format:

application/pdf

Resource Identifier:

0860-7796 ; IChB B-64

Source:

Biblioteka Instytutu Chemii Bioorganicznej PAN

Language:

pol

Language of abstract:

eng

Temporal coverage:

1988-2010

Rights:

Licencja Creative Commons Uznanie autorstwa-Na tych samych warunkach 4.0

Terms of use:

-

Digitizing institution:

Instytut Chemii Bioorganiczneji Polskiej Akademii Nauk

Original in:

Instytut Chemii Bioorganiczneji Polskiej Akademii Nauk

Projects co-financed by:

Program Operacyjny Polska Cyfrowa, lata 2014-2020, Działanie 2.3 : Cyfrowa dostępność i użyteczność sektora publicznego; środki z Europejskiego Funduszu Rozwoju Regionalnego oraz współfinansowania krajowego z budżetu państwa

Access:

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