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Lizostaiyna - źródła otrzymywania i zastosowanie
Subtitle:Lysostaphin - sources and applications
Creator:Szweda, Piotr ; Kotłowski, Roman ; Kur, Józef
Publisher:Komitet Biotechnologii PAN ; Instytut Chemii Bioorganicznej PAN
Date issued/created: Subject and Keywords: Abstract:Lysostaphin is a zinc metalloproteinase extracted from Staphylococcus simulans biovar staphylolyticus that degrades the cell wall of almost all known staphylococcal species. The target of the lysostaphin activity is the pentaglycine interpeptide bridges of the unique staphylococcal peptidoglycan, where the enzyme cleaves the Gly-Gly bond and lyses cells in all metabolic states (growing, resting, or heat killed). The specificity of the pentaglycine peptide is very high and other gram-positive and gram-negative bacteria are not susceptible to this enzyme. The unique biological activity of lysostaphin presents numerous possibilities for applications of this enzyme in the medical, veterinary, food industry and research fields. Lysostaphin is frequently used as a staphylolytic agent for the liberation of intracellular enzymes, nucleic acids, and cell membrane and surface components. Lysostaphin was tested as a chemotherapeutic agent. Lysostaphin application was also shown to be effective in reducing the nasal carriage of S. aureus in humans. There are also examples for application of this enzyme in food protection.
Relation:Biotechnologia, vol.71, 4 (2005)-.
Volume: Issue: Start page: End page: Resource type: Detailed Resource Type: Format: Resource Identifier: Source:Biblioteka Instytutu Chemii Bioorganicznej PAN
Language: Language of abstract: Temporal coverage: Rights:Licencja Creative Commons Uznanie autorstwa-Na tych samych warunkach 4.0
Terms of use: Digitizing institution:Instytut Chemii Bioorganicznej Polskiej Akademii Nauk
Original in:Instytut Chemii Bioorganicznej Polskiej Akademii Nauk
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