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Nucleosides modified in the 2’ and 3’ positions are known for many years and involve many important, bioactive compounds. This group consist of derivatives of 2’,3’-dideoxy or 2’,3’-dideoxy-didehydro types, derivatives with additional substituents or substituents instead of hydroxyl groups. These compounds are targeted against viruses and tumors. Anhydrocyclic structures have been known since the middle of the 20th century. However, their utility seems not to be fully explored and described. The number of possible to obtain through anhydrocyclic synthons 2’,3’-dimodified derivatives is very vast, taking under consideration different combinations of S-alkyl, S-aryl, O-alkyl, O-aryl, halogen, triazole, amine and azide substituents in both pyrimidine and purine nucleosides.
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Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.