Metadata language
Majewska, Maria D. ; Lazarewicz Jerzy, W. ; Strosznajder, Joanna
Publisher: Place of publishing: Date issued/created: Type of object: Abstract:The degradation process of mitochondrial membrane phospholipids from guinea pig brain was studied in conditions of ischemia and barbiturate anesthesia. Ischemia resulted in the decrease of phosphatidylethanolamine (PE) level and in the increase of the content of free fatty acids (FFA). Calcium ions were activating PE hydrolysis and FFA release and may be the factor stimulating the activity of mitochondrial phospholipase in conditions of oxygen defficiency. The in vilro studies demonstrate that procain and the ATP+MgJ + system strongly inhibit the activity of mitochondrial phospholipase, while nembutal has no effect. Ncmbutal anesthesia decreases the hydrolytic changes of phospholipids, produced by ischemia. It is suggested that besides the geneial metabolic and physioiogical state of the celi, produced by anesthesia acetylcholine, which level in the braip is inereased twi<_e during barbiturate anesthesia, may be one of the factors of anesthesia responsible for the protection of brain mitochondriu against ischemia. In vitro, acetylcholine inhibits the activity of the mitochondrial phospholipase.
Relation:Bulletin de l'Academie Polonaise des Sciences. Serie des Sciences Biologiques
Volume: Issue: Start page: End page: Resource type: Detailed Resource Type: Format: Language: Language of abstract: Rights:Licencja Creative Commons Uznanie autorstwa 4.0
Terms of use:Zasób chroniony prawem autorskim. [CC BY 4.0 Międzynarodowe] Korzystanie dozwolone zgodnie z licencją Creative Commons Uznanie autorstwa 4.0, której pełne postanowienia dostępne są pod adresem: ; -
Copyright holder: Digitizing institution:Instytut Medycyny Doświadczalnej i Klinicznej im. M. Mossakowskiego Polskiej Akademii Nauk
Original in:Biblioteka Instytutu Medycyny Doświadczalnej i Klinicznej im. M. Mossakowskiego PAN
Projects co-financed by: Access: