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		<identifier>oai:rcin.org.pl:138884</identifier>
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<dc:title xml:lang="en"><![CDATA[Thiol-activated hemolysins as virulence markers of bacteria]]></dc:title>
<dc:title xml:lang="pl"><![CDATA[Thiol-activated hemolysins as virulence markers of bacteria]]></dc:title>
<dc:title xml:lang="pl"><![CDATA[Hemolizyny aktywowane tiolem jako markery wirulencji bakterii]]></dc:title>
<dc:creator><![CDATA[Szramka, Bożena]]></dc:creator>
<dc:creator><![CDATA[Kurlenda, Julianna]]></dc:creator>
<dc:creator><![CDATA[Podhajska, Anna J.]]></dc:creator>
<dc:subject xml:lang="en"><![CDATA[biotechnology]]></dc:subject>
<dc:subject xml:lang="pl"><![CDATA[biotechnologia]]></dc:subject>
<dc:description xml:lang="en"><![CDATA[The article contains information regarding the similarities and differencesbetween proteins of the thiol-activated cytolysins family (TACY). Members ofthis group of haemolysins are produced by several species of Gram-positive bacteria {Listeria spp., Streptococcus spp., Bacillus spp., Clostridium spp.,) and also byGram-negative Klebsiella spp. Their cytolytic activity is sensitive to oxygen andcan be restored by adding reducing compounds. TACY bind to cholesterol-containing membranes to form pores. Preincubation of the toxin with smallamounts of cholesterol inhibits hemolytic activity as well as cytolysis ofeucaryotic cells. Members ofthe group show 40-70% similarity in amino acid sequence, and contain an almost invariant Trp-rich undecapeptide sequence(ECTGLAWEWWR). The TACY are important virulence factors. Recently increased use has been made of molecular methods (PCR, hybridization) in the detection and identification of the TACY producing bacteria.]]></dc:description>
<dc:description xml:lang="pl"><![CDATA[The article contains information regarding the similarities and differencesbetween proteins of the thiol-activated cytolysins family (TACY). Members ofthis group of haemolysins are produced by several species of Gram-positive bacteria {Listeria spp., Streptococcus spp., Bacillus spp., Clostridium spp.,) and also byGram-negative Klebsiella spp. Their cytolytic activity is sensitive to oxygen andcan be restored by adding reducing compounds. TACY bind to cholesterol-containing membranes to form pores. Preincubation of the toxin with smallamounts of cholesterol inhibits hemolytic activity as well as cytolysis ofeucaryotic cells. Members ofthe group show 40-70% similarity in amino acid sequence, and contain an almost invariant Trp-rich undecapeptide sequence(ECTGLAWEWWR). The TACY are important virulence factors. Recently increased use has been made of molecular methods (PCR, hybridization) in the detection and identification of the TACY producing bacteria.]]></dc:description>
<dc:publisher><![CDATA[Committee on Biotechnology PAS]]></dc:publisher>
<dc:publisher><![CDATA[Institute of Bioorganic Chemistry PAS]]></dc:publisher>
<dc:publisher><![CDATA[Komitet Biotechnologii PAN]]></dc:publisher>
<dc:publisher><![CDATA[Instytut Chemii Bioorganicznej PAN]]></dc:publisher>
<dc:date><![CDATA[2001]]></dc:date>
<dc:type xml:lang="en"><![CDATA[Text]]></dc:type>
<dc:type xml:lang="pl"><![CDATA[Tekst]]></dc:type>
<dc:format xml:lang="en"><![CDATA[application/pdf]]></dc:format>
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<dc:identifier><![CDATA[0860-7796]]></dc:identifier>
<dc:identifier><![CDATA[IChB B-50]]></dc:identifier>
<dc:identifier><![CDATA[https://rcin.org.pl/dlibra/publication/174177/edition/138884/content]]></dc:identifier>
<dc:identifier><![CDATA[oai:rcin.org.pl:138884]]></dc:identifier>
<dc:source xml:lang="en"><![CDATA[Library of Institute of Bioorganic Chemistry PAS]]></dc:source>
<dc:source xml:lang="pl"><![CDATA[Biblioteka Instytutu Chemii Bioorganicznej PAN]]></dc:source>
<dc:language><![CDATA[pol]]></dc:language>
<dc:relation><![CDATA[Biotechnologia, vol.54, 3 (2001)-.]]></dc:relation>
<dc:relation><![CDATA[oai:rcin.org.pl:publication:174177]]></dc:relation>
<dc:rights xml:lang="en"><![CDATA[Creative Commons Attribution BY-SA 4.0 license]]></dc:rights>
<dc:rights xml:lang="pl"><![CDATA[Licencja Creative Commons Uznanie autorstwa-Na tych samych warunkach 4.0]]></dc:rights>
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