@misc{Godawska_Anna_The_2005,
 author={Godawska, Anna and Pękala, Elżbieta and Kieć-Kononowicz, Katarzyna},
 volume={68},
 number={1},
 copyright={Creative Commons Attribution BY-SA 4.0 license},
 journal={Biotechnologia, vol.68, 1 (2005)-.},
 howpublished={online},
 year={2005},
 publisher={Committee on Biotechnology PAS},
 publisher={Institute of Bioorganic Chemistry PAS},
 language={pol},
 abstract={Praziquantel (PZQ) is a drug which is used by choice to schistosomiasis treatment. Currently, it is used in malaria treatment. PZQ undergoes extensive metabolism in human body, mainly in liver, by two cytochrome P-450 isoenzymes 2B1 and 3A. As a result of these biotransformations, numerous mono- and dihydroxylated derivates in B, C and D rings are formed. Only one metabolite has been identified and described, it is 4-hydroxypraziquantel (4-OH-PZQ). So far, the metabolites out of PZQ biotransformation were obtained under the influence of Ciinnighamelle echinulata and Beauveria bassiana. There were the derivatives in position C7 and in D-ring (position is unknown).},
 title={The comparison of praziquantel biotransformation in silico and in vitro},
 type={Text},
 URL={http://www.rcin.org.pl/Content/112068/PDF/POZN271_140338_biotechnologia-2005-no1-godawska.pdf},
 keywords={biotechnology},
}